Biomaterials in Immune Engineering Books

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Biomaterials and Immune Response


Biomaterials and Immune Response
  • Author : Nihal Engin Vrana
  • Publisher : CRC Press
  • Release : 2018-07-20
  • ISBN : 9781351377553
  • Language : En, Es, Fr & De
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The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Engineering Zwitterionic Biomaterials for Immune Modulation and Drug Delivery


Engineering Zwitterionic Biomaterials for Immune Modulation and Drug Delivery
  • Author : Bowen Li
  • Publisher :
  • Release : 2019
  • ISBN : OCLC:1117497623
  • Language : En, Es, Fr & De
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The development of biotherapeutics, which hold promising potential to treat diverse disease, is limited by their inadequate circulation half-lives and inherent immunogenicity. Conjugation of non-ionic poly (ethylene glycol) (PEG), known as PEGylation, has been widely employed as the gold standard to ameliorate the pharmacokinetic (PK) and immunological profiles of proteins. Unfortunately, PEG grafted onto immunogenic proteins has been shown to induce anti-PEG antibodies (Abs) that could cause loss of efficacy and even lethal adverse reactions. To confront the "PEG dilemma", zwitterionic materials with superhydrophilicity are emerging as promising alternatives for PEG. This dissertation summarizes recent studies from the design, synthesis and characterization of zwitterionic polymers to the in vitro and in vivo studies of poly(zwitterion)- protein nanomedicine. The influence of PEG and zwitterionic poly(carboxy betaine) (PCB) on immune systems is firstly discussed, revealing the low immunogenic risk of zwitterionic materials. Based on this design principle, new protein-delivery tactics are proposed to avoid the generation of undesirable immune responses, either by completely shielding proteins from immune recognition or by actively inducing antigen-specific immune tolerance. Furthermore, new classes of naturally-inspired inert or immunomodulatory zwitterionic materials are developed to further improve the efficacy and safety of protein therapeutics, enriching the arsenal of biomaterial tools for drug delivery.

Immunomodulatory Biomaterials


Immunomodulatory Biomaterials
  • Author : Stephen F. Badylak
  • Publisher : Woodhead Publishing
  • Release : 2021-08-01
  • ISBN : 9780128214565
  • Language : En, Es, Fr & De
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Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Biomaterials for Organ and Tissue Regeneration


Biomaterials for Organ and Tissue Regeneration
  • Author : Nihal Vrana
  • Publisher : Woodhead Publishing
  • Release : 2020-03-20
  • ISBN : 9780081029077
  • Language : En, Es, Fr & De
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Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects examines the use of biomaterials in applications related to artificial tissues and organs. With a strong focus on fundamental and traditional tissue engineering strategies, the book also examines how emerging and enabling technologies are being developed and applied. Sections provide essential information on biomaterial, cell properties and cell types used in organ generation. A section on state-of-the-art in organ regeneration for clinical purposes is followed by a discussion on enabling technologies, such as bioprinting, on chip organ systems and in silico simulations. Provides a systematic overview of the field, from fundamentals, to current challenges and opportunities Encompasses the classic paradigm of tissue engineering for creation of new functional tissue Discusses enabling technologies such as bioprinting, organ-on-chip systems and in silico simulations

Host Response to Biomaterials


Host Response to Biomaterials
  • Author : Stephen F Badylak
  • Publisher : Academic Press
  • Release : 2015-05-08
  • ISBN : 9780128005002
  • Language : En, Es, Fr & De
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Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions. Fields covered include, but are not limited to, orthopaedic surgery, dentistry, general surgery, neurosurgery, urology, and regenerative medicine. Explains the various categories of biomaterials and their significance for clinical applications Contains a range of extensive coverage, including, but not limited to, orthopedic, surgery, dental, general surgery, neurosurgery, lower urinary tract, and regenerative medicine Includes regulations regarding combination devices