Deterministic Versus Stochastic Modelling in Biochemistry and Systems Biology Books

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Deterministic Versus Stochastic Modelling in Biochemistry and Systems Biology


Deterministic Versus Stochastic Modelling in Biochemistry and Systems Biology
  • Author : Paulo Lecca
  • Publisher : Elsevier
  • Release : 2013-04-09
  • ISBN : 9781908818218
  • Language : En, Es, Fr & De
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Stochastic kinetic methods are currently considered to be the most realistic and elegant means of representing and simulating the dynamics of biochemical and biological networks. Deterministic versus stochastic modelling in biochemistry and systems biology introduces and critically reviews the deterministic and stochastic foundations of biochemical kinetics, covering applied stochastic process theory for application in the field of modelling and simulation of biological processes at the molecular scale. Following an overview of deterministic chemical kinetics and the stochastic approach to biochemical kinetics, the book goes onto discuss the specifics of stochastic simulation algorithms, modelling in systems biology and the structure of biochemical models. Later chapters cover reaction-diffusion systems, and provide an analysis of the Kinfer and BlenX software systems. The final chapter looks at simulation of ecodynamics and food web dynamics. Introduces mathematical concepts and formalisms of deterministic and stochastic modelling through clear and simple examples Presents recently developed discrete stochastic formalisms for modelling biological systems and processes Describes and applies stochastic simulation algorithms to implement a stochastic formulation of biochemical and biological kinetics

Computational Systems Biology


Computational Systems Biology
  • Author : Jean-Christophe Leloup
  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-11-26
  • ISBN : 9780128070116
  • Language : En, Es, Fr & De
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Circadian rhythms originate from intertwined feedback processes in genetic regulatory networks. Computational models of increasing complexity have been proposed for the molecular mechanism of these rhythms, which occur spontaneously with a period on the order of 24h. We show that deterministic models for circadian rhythms in Drosophila account for a variety of dynamical properties, such as phase shifting or long-term suppression by light pulses and entrainment by light/dark cycles. Stochastic versions of these models allow us to examine how molecular noise affects the emergence and robustness of circadian oscillations. Finally, we present a deterministic model for the mammalian circadian clock and use it to address the dynamical bases of physiological disorders of the sleep/wake cycle in humans.

Computational Systems Biology


Computational Systems Biology
  • Author : Andres Kriete
  • Publisher : Elsevier
  • Release : 2005-11-10
  • ISBN : 008045934X
  • Language : En, Es, Fr & De
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Systems Biology is concerned with the quantitative study of complex biosystems at the molecular, cellular, tissue, and systems scales. Its focus is on the function of the system as a whole, rather than on individual parts. This exciting new arena applies mathematical modeling and engineering methods to the study of biological systems. This book is the first of its kind to focus on the newly emerging field of systems biology with an emphasis on computational approaches. The work covers new concepts, methods for information storage, mining and knowledge extraction, reverse engineering of gene and metabolic networks, as well as modelling and simulation of multi-cellular systems. Central themes include strategies for predicting biological properties and methods for elucidating structure-function relationships.

Synthetic Biology a Primer revised Edition


Synthetic Biology   a Primer  revised Edition
  • Author : Paul S. FREEMONT
  • Publisher : World Scientific
  • Release : 2015-08-24
  • ISBN : 9781783268801
  • Language : En, Es, Fr & De
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Theoretical Physics for Biological Systems


Theoretical Physics for Biological Systems
  • Author : Paola Lecca
  • Publisher : CRC Press
  • Release : 2019-01-30
  • ISBN : 9781351374323
  • Language : En, Es, Fr & De
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Quantum physics provides the concepts and their mathematical formalization that lend themselves to describe important properties of biological networks topology, such as vulnerability to external stress and their dynamic response to changing physiological conditions. A theory of networks enhanced with mathematical concepts and tools of quantum physics opens a new area of biological physics, the one of systems biological physics.