Domino Reactions in Drug Discovery Books

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Domino Reactions in Drug Discovery


Domino Reactions in Drug Discovery
  • Author : Shanta Bhar
  • Publisher : Elsevier
  • Release : 2020-10
  • ISBN : 0128193743
  • Language : En, Es, Fr & De
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Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending enhanced efficiency and synthetic versatility to pharmaceutical drug design. Due to their atom economy, these reactions are increasingly popular in the development of complex scaffolds and multifunctional derivatives aimed at the synthesis of new chemical entities and approved APIs across diverse therapeutic classes, including antidiabetics [DPP4 inhibitors], anticancer therapies and HIV integrase inhibitors. Features illustrated schemes with mechanisms, procedures and results Includes a compendium of Domino Name Reactions for drugs Provides a concise, comprehensive coverage of domino reactions in drug discovery, with a focus on sustainable practices

Synthesis of Aromatic Heterocycles by Palladium 0 catalyzed Domino Reactions and Cyclization of Hydrazone Dianions


Synthesis of Aromatic Heterocycles by Palladium 0  catalyzed Domino Reactions and Cyclization of Hydrazone Dianions
  • Author : Thang Ngoc Ngo
  • Publisher :
  • Release : 2016
  • ISBN : OCLC:968149399
  • Language : En, Es, Fr & De
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Domino Reactions in Organic Synthesis


Domino Reactions in Organic Synthesis
  • Author : Lutz F. Tietze
  • Publisher : John Wiley & Sons
  • Release : 2006-12-13
  • ISBN : 9783527608683
  • Language : En, Es, Fr & De
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Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.

Domino Reactions


Domino Reactions
  • Author : Lutz F. Tietze
  • Publisher : John Wiley & Sons
  • Release : 2013-12-23
  • ISBN : 9783527671328
  • Language : En, Es, Fr & De
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The follow-up to the successful "Domino Reaction in Organic Synthesis", this ready reference brings up to date on the original concept. The chapters have been arranged according to the name of well-known transformations of the first step and in combination with the formed products. Each chapter is written by an internationally renowned expert, and the book is edited by L. F. Tietze, who established the concept of domino reactions. The one-stop source for all synthetic chemists to improve the synthetic efficiency and allow an ecologically and economically beneficial preparation of every chemical compound.

Asymmetric Domino Reactions


Asymmetric Domino Reactions
  • Author : Helene Pellissier
  • Publisher : Royal Society of Chemistry
  • Release : 2013-03-13
  • ISBN : 9781849737104
  • Language : En, Es, Fr & De
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This book covers the latest developments in asymmetric domino reactions, focussing on those published in the last 6 years. These fascinating reactions have rapidly become one of the most current fields in organic chemistry, since they allow reaching easily high molecular complexity in an economically favourable way with advantages of savings in solvent, time, energy, and costs. Unsurprisingly, the high levels of efficiency and enantioselectivity generally reached in these reactions have been exploited for the production of a wide number of complex chiral molecules with dense stereochemistry and functionality, which are motifs present in biologically active compounds and natural products. The book is divided into three principal sections, dealing successively with asymmetric domino reactions based on the use of chiral auxiliaries, asymmetric domino reactions based on the use of chiral metal catalysts, and asymmetric domino reactions based on the use of chiral organocatalysts, covering the literature since the beginning of 2006.