Eosinophil Ultrastructure Books

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Eosinophil Ultrastructure


Eosinophil Ultrastructure
  • Author : Rossana C.N. Melo
  • Publisher : Academic Press
  • Release : 2021-05-01
  • ISBN : 9780128137567
  • Language : En, Es, Fr & De
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Eosinophil Ultrastructure: Atlas of Eosinophil Cell Biology and Pathology focuses on eosinophils and their functional roles in inflammation, host defense and normal homeostatic activities. The book explores the ultrastructure of human eosinophils, highlighting biological processes observed in normal, experimental and pathological conditions. Created to fill a void in the eosinophil literature, this book has an extensive array of electron microscopic images that illustrate the diversity of eosinophil morphology. While the atlas is primarily a learning and teaching tool, it also acts as a helpful resource for researchers who want to identify distinguishing features and structural changes that arise during studies of human eosinophils. Helps readers understand human eosinophils in studies focused on structural biology, cellular immunology, innate and adaptive immunity, immune responses to pathogens, immunopathology and inflammatory responses Provides a core of essential knowledge to identify both immature and mature eosinophils Comprises a representative compilation of the eosinophil ultrastructure during biological processes, such as activation and degranulation, observed mostly in experimental conditions Highlights eosinophil biological processes found in vivo during human diseases, thus providing a link between basic science and clinical aspects Helps identify distinguishing features and structural changes that arise during studies of human eosinophils in culture

Functional Ultrastructure


Functional Ultrastructure
  • Author : Margit Pavelka
  • Publisher : Springer Science & Business Media
  • Release : 2005-12-05
  • ISBN : 9783211263921
  • Language : En, Es, Fr & De
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The period between 1950 and 1980 were the golden It also provides unique insights into how pathological years of transmission electron microscopy and pro- processes affect cell organization. duced a plethora of new information on the structure of This information is vital to current work in which cells that was coupled to and followed by biochemical the emphasis is on integrating approaches from p- and functional studies. TEM was king and each micro- teomics, molecular biology, molecular imaging and graph of a new object produced new information that physiology, and pathology to understand cell functions led to new insights on cell and tissue organization and and derangements in disease. In this current era, there is their functions. The quality of data represented by the a growing tendency to substitute modern light mic- images of cells and tissues had been perfected to a very scopic techniques for electron microscopy because it is high level by the great microscopists of the era including less technically demanding and is more readily available Palade, Porter, Fawcett, Sjostrand, Rhodin and many to researchers. This atlas reminds us that the infor- others. At present, the images that we see in leading tion obtained by electron microscopy is invaluable and journals for the most part do not reach the same techni- has no substitute.

Topical Reviews in Haematology


Topical Reviews in Haematology
  • Author : Stuart Roath
  • Publisher : Elsevier Health Sciences
  • Release : 1982-06
  • ISBN : 0723606153
  • Language : En, Es, Fr & De
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Eosinophils in Health and Disease


Eosinophils in Health and Disease
  • Author : James J. Lee
  • Publisher : Elsevier
  • Release : 2012-12-31
  • ISBN : 9780123946072
  • Language : En, Es, Fr & De
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Written and edited by leaders in the field, Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance. Despite an explosion of discovery in this area over the last decade, this is the only up-to-date resource on eosinophils and eosinophilia exists. This full-color volume provides an essential collection of world class information that is a must-have for any immunologist’s workbench or bookshelf. The only updated, comprehensive source of information on eosinophils on the market Written by over 80 leaders in the field Holistic view of the subject, including basic science, disease-specific chapters, therapeutic options and emerging areas of research

Pathogenic Advances and Therapeutic Perspectives for Eosinophilic Inflammation


Pathogenic Advances and Therapeutic Perspectives for Eosinophilic Inflammation
  • Author : Florence E. Roufosse
  • Publisher : Frontiers Media SA
  • Release : 2018-12-06
  • ISBN : 9782889456246
  • Language : En, Es, Fr & De
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With the recent approval of the first eosinophil-depleting therapeutic agents targeting the IL-5 pathway for treatment of severe eosinophilic asthma, eosinophils and eosinophilic disorders are in the limelight. Indeed, setbacks during clinical development of these compounds have revealed how much remains to be known about eosinophil biology in vivo, and have nurtured profuse research both on basic eosinophil biology and on pathogenic disease mechanisms, in order to better delineate the most meaningful targets for innovative therapeutic strategies. On one hand, variable degrees of eosinophil depletion observed in some compartments during IL-5-targeted treatment indicate that certain eosinophil subsets may not rely on this cytokine and/or that other important pro-eosinophilic mediators and signaling pathways are operative in vivo. On the other hand, it is increasingly clear that disorders involving eosinophils such as asthma are the final outcome of complex interactions between diverse cell types and mediators, beyond eosinophils and IL-5. These include type 2 helper T (Th2) cells and innate lymphoid cells, mast cells, and a variety of factors that either activate eosinophils or are released by them. Although a considerable amount of research has focused on asthma because it is a common condition and because management of severe asthma remains a major challenge, several rare eosinophilic disorders with more homogenous features have proven to be extremely useful models to reach a better understanding of the involvement of eosinophils in tissue damage and dysfunction, and of the micro-environmental interactions operating within the complex network of eosinophilic inflammation. Unraveling this interplay has resulted in advances in the development of molecular tools to detect disease subsets and to monitor therapeutic responses, and in identification of promising new therapeutic targets. This Research Topic dedicated to eosinophilic conditions covers aspects of the biology of eosinophils and closely related cells of particular relevance for drug development, reports on translational research investigating pathogenic mechanisms of specific eosinophilic disorders in humans that will likely result in significant changes in the way patients are managed, and presents an overview of the current advancement of targeted drug development for these conditions, with a special focus on asthma.