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Epigenetics of the Immune System


Epigenetics of the Immune System
  • Author : Dieter Kabelitz
  • Publisher : Academic Press
  • Release : 2020-07-03
  • ISBN : 9780128179642
  • Language : En, Es, Fr & De
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Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications. Provides an overview of most important immune mechanisms, the current status of epigenetics, and how both of them are brought together Presents key principles of immune mechanisms in epigenetics, presenting current findings and key principles Features in-depth chapter contributions from a wide range of international researchers and specialists in immunology, translational medicine and epigenetics Merges two very large areas, covering the unique interrelatedness of epigenetics and immunology

Epigenetics of the Immune System


Epigenetics of the Immune System
  • Author : Dieter Kabelitz
  • Publisher : Academic Press
  • Release : 2020-06-04
  • ISBN : 9780128179659
  • Language : En, Es, Fr & De
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Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications. Provides an overview of most important immune mechanisms, the current status of epigenetics, and how both of them are brought together Presents key principles of immune mechanisms in epigenetics, presenting current findings and key principles Features in-depth chapter contributions from a wide range of international researchers and specialists in immunology, translational medicine and epigenetics Merges two very large areas, covering the unique interrelatedness of epigenetics and immunology

The Epigenetics of Autoimmunity


The Epigenetics of Autoimmunity
  • Author : Rongxin Zhang
  • Publisher : Academic Press
  • Release : 2018-04-25
  • ISBN : 9780128099285
  • Language : En, Es, Fr & De
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The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment. Provides the accurate and cutting-edge information on autoimmunity epigenetics Wide coverage appeals to those interested in fundamental epigenetics and inheritance to those with more clinical interests Critical reviews of the mean of deriving and analysing autoimmunity epigenetics information as well as its translational potential Up-to-date coverage of emerging topics in autoimmunity epigenetics

Human Epigenetics How Science Works


Human Epigenetics  How Science Works
  • Author : Carsten Carlberg
  • Publisher : Springer Nature
  • Release : 2019-09-24
  • ISBN : 9783030229078
  • Language : En, Es, Fr & De
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The view “It’s all in our genes and we cannot change it” developed in the past 150 years since Gregor Mendel’s experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and present the onset of diseases, such a type 2 diabetes or cancer. This textbook provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells of our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described. The book represents an updated but simplified version of our textbook “Human Epigenomics” (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.

Epigenetic Dynamics in the Immune System


Epigenetic Dynamics in the Immune System
  • Author : Sudha Rao
  • Publisher : Academic Press
  • Release : 2018-01-01
  • ISBN : 9780128045732
  • Language : En, Es, Fr & De
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Epigenetic Dynamics in the Immune System: Impact in Health and Disease discusses how epigenetic changes and disturbances to immune cells can lead to immune disorders. This volume will provide an up-to-date look at the current state-of-the-art epigenomic technologies, and each chapter will form a comprehensive overview of the latest research written by international leaders in their field. Opening with both an introduction to epigenetics and an introduction to immunology, the book goes on to explore the role of epigenetics in regulating normal immune functions, immune disorders, and finally their potential as novel therapeutic targets. This multidisciplinary work is an essential resource to researchers who want to better understand the most recent developments in this research area, as well as clinicians who are interested in epigenetic approaches to treating immune diseases. This book will also be an excellent text for students as well, as it ties together two fields that are interrelated but often taught separately. Provides an access point into the current literature on epigenetics in the immune system, dysregulation in disease and therapeutic opportunities for researchers and clinicians Discusses the most recent advances by international leaders in the field, including the latest tools and technologies used in novel epigenetic therapies treating immune disorders Brings together two distinct fields of genetics and immunology and is relevant to clinicians, researchers, and students in both areas