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Eukaryotic Transcription Factors


Eukaryotic Transcription Factors
  • Author : David S. Latchman
  • Publisher :
  • Release : 1995
  • ISBN : UOM:39076001892665
  • Language : En, Es, Fr & De
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"Understanding the mechanisms of eukaryotic gene regulation is essential for students and scientists working in a wide range of clinical and basic disciplines. However, keeping track of the vast number of transcription factors which are central to gene regulation can prove daunting. The fourth edition of Eukaryotic Transcription Factors not only provides the reader with a clear and concise understanding of transcription factors but also of their vital role in the regulation of transcription in different cell types during development, in response to specific stimuli and in disease."--BOOK JACKET.

Eukaryotic Transcription Factors


Eukaryotic Transcription Factors
  • Author : David S. Latchman
  • Publisher : Academic Press
  • Release : 2003-11-21
  • ISBN : 9780080531267
  • Language : En, Es, Fr & De
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Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors. This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality. * Major families of eukaryotic transcription factors described * Mechanisms of gene activation and repression analysed * Structure-function relationships indicated * Interaction between transcription factors and chromatin structure described * Roles in inducible and cell type-specific gene expression * Roles in development, differentiation and human diseases including cancer * Methods of study in vitro and in vivo

Eukaryotic Transcription Factors


Eukaryotic Transcription Factors
  • Author : David S. Latchman
  • Publisher :
  • Release : 1998-11-30
  • ISBN : 0132471760
  • Language : En, Es, Fr & De
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The third edition of Eukaryotic Transcription Factors has been rewritten to reflect advances in the field. These include the emerging roles of specific co-activator molecules such as CBP in the action of a number of different transcription factors emphasising particularly their ability to modulate chromatin structure.

A Handbook of Transcription Factors


A Handbook of Transcription Factors
  • Author : Timothy R. Hughes
  • Publisher : Springer Science & Business Media
  • Release : 2011-05-10
  • ISBN : 904819069X
  • Language : En, Es, Fr & De
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Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.

Gene Control


Gene Control
  • Author : David Latchman
  • Publisher : Garland Science
  • Release : 2018-03-29
  • ISBN : 9781136844201
  • Language : En, Es, Fr & De
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Gene Control offers a current description of how gene expression is controlled in eukaryotes, reviewing and summarizing the extensive primary literature into an easily accessible format. Gene Control is a comprehensively restructured and expanded edition of Latchman’s Gene Regulation: A Eukaryotic Perspective, Fifth Edition. The first part of the book deals with the fundamental processes of gene control at the levels of chromatin structure, transcription, and post-transcriptional processes. Three pairs of chapters deal with each of these aspects, first describing the basic process itself, followed by the manner in which it is involved in controlling gene expression. The second part of the book deals with the role of gene control in specific biological processes. Certain chapters deal with the importance of gene control in cellular signaling processes and for normal development of the embryo. Another chapter discusses the key roles played by gene-regulatory processes in the specification of differentiated cell types such as muscle cells and neurons. The final chapters discuss the consequences of errors in gene control; the relationship between gene misregulation and human diseases, especially cancer; and potential therapies designed specifically to target particular levels of gene control. Gene Control will be of value to students in biological sciences, as well as to scientists and clinicians interested in how genes are regulated in health and disease.