Fibroblast Growth Factor 23 Books

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Fibroblast Growth Factor 23


Fibroblast Growth Factor 23
  • Author : Christian Faul
  • Publisher : Elsevier
  • Release : 2021-04-06
  • ISBN : 9780128180372
  • Language : En, Es, Fr & De
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Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology and nephrology, making this book an ideal reference source on FGF23. Provides a comprehensive collection of chapters on the diversity of FGF23's actions Highlights truly translational topics, from molecular signaling to physiology and mechanism of disease, discussing cell culture and animal models to study FGF23 Describes FGF23’s potential in the clinical setting as a biomarker or even drug target Presents leaders in the field who cover a wide spectrum of research backgrounds and expertise, including clinical and basic scientists who specialize in diseases, endocrinology, genetics, protein biochemistry, cell biology and physiology

Phosphate Metabolism


Phosphate Metabolism
  • Author : Shaul Massry
  • Publisher : Springer Science & Business Media
  • Release : 2013-11-21
  • ISBN : 9781461342175
  • Language : En, Es, Fr & De
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We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.

Current Perspectives in Kidney Diseases


Current Perspectives in Kidney Diseases
  • Author : G. La Manna
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 2017-05-23
  • ISBN : 9783318060614
  • Language : En, Es, Fr & De
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After years of stagnation, much has been happening in the diagnosis and treatment of kidney diseases. This book contains a comprehensive review of the main developments in AKI, CKD, hemodialysis and kidney transplantation. The section on AKI deals with the key innovations in extracorporeal technologies. The section on nephrology and CKD concentrates on mineral metabolism alterations, restenosis in hemodialytic fistulas, mycophenolate mofetil as an alternative treatment for IgA nephropathy, and the genetics and progression of autosomal dominant polycystic kidney disease. The part on hemodialysis includes contributions on expanded hemodialysis, potassium profiling and home hemodialysis. Chapters on the treatment of acute antibody-mediated rejection after transplantation, pathogenesis and therapy of chronic allograft injury, and non-invasive surrogate biomarkers of acute rejection round out the subjects covered. Due to the wide variety of topics included in each section, this book is not only of interest to nephrologists, but also to professionals from related fields.

Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease


Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease
  • Author : Reinhold G. Erben
  • Publisher : Frontiers Media SA
  • Release : 2019-04-05
  • ISBN : 9782889458059
  • Language : En, Es, Fr & De
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αKlotho and fibroblast growth factor-23 (FGF23) were discovered independently about 20 years ago. Since their initial description, a series of exciting discoveries have revealed the important role of endocrine and paracrine FGF23 and αKlotho signaling not only for the physiological regulation of mineral and bone homeostasis, but also for the pathophysiology of diseases such as chronic kidney disease, left ventricular hypertrophy, myocardial infarction, hypertension, and disorders characterized by impaired bone mineralization. The 11 articles compiled in this Research Topic consist of three Original Research articles and 8 Reviews or Mini Reviews, and are an excellent source of information about the state of the art in the FGF23/αKlotho field, covering almost all aspects of FGF23/αKlotho biology.

Endocrine FGFs and Klothos


Endocrine FGFs and Klothos
  • Author : Makoto Kuro-o
  • Publisher : Springer Science & Business Media
  • Release : 2012-03-06
  • ISBN : 9781461408871
  • Language : En, Es, Fr & De
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Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.