Histopathology of Preclinical Toxicity Studies Books

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Histopathology of Preclinical Toxicity Studies


Histopathology of Preclinical Toxicity Studies
  • Author : Peter Greaves
  • Publisher : Academic Press
  • Release : 2011-11-22
  • ISBN : 9780444538567
  • Language : En, Es, Fr & De
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Chapter 1: Introduction -- Chapter 2: Integumentary System -- -- Skin and subcutaneous tissue -- Chapter 3: Mammary Gland -- Chapter 4: Haemopoietic and Lymphatic Systems -- -- Blood/bone marrow -- -- Lymphoid system -- -- Lymph nodes -- -- Spleen -- -- Thymus -- -- Lymphoreticular neoplasms -- Chapter 5: Musculoskeletal System -- -- Bone -- -- Joints -- -- Skeletal muscle -- Chapter 6: Respiratory Tract -- -- Nose, nasal sinuses, nasopharynx and pharynx -- -- Larynx and trachea -- -- Bronchi and lungs -- Chapter 7: Cardiovascular System -- -- Heart and pericardium -- -- Systemic blood vessels -- -- Pulmonary blood vessels -- Chapter 8: Gastrointestinal tract -- -- Forestomach -- -- Stomach (glandular) -- -- Small intestine -- -- Large intestine -- Chapter 9: Liver and Pancreas -- -- Liver -- -- Bile ducts, biliary system -- -- Pancreas -- Chapter 10: Urinary System -- -- Kidney -- -- Urinary bladder -- Chapter 11: Male Genital Tract -- -- Prostate gland -- -- Epididymis -- -- Testis -- Chapter 12: Female Genital Tract -- -- Vagina -- -- Cervix -- -- Uterus -- -- Ovary -- Chapter 13: Endocrine System -- -- Pituitary gland -- -- Adrenal gland -- -- Thyroid gland -- -- Parathyroid gland -- Chapter 14: Nervous System and Special Sense Organs -- -- Brain -- -- Spinal cord, spinal nerve roots, peripheral nerves -- -- Eye -- -- Ear -- Subject index

Histopathology of Preclinical Toxicity Studies


Histopathology of Preclinical Toxicity Studies
  • Author : Peter Greaves
  • Publisher : Elsevier Science Limited
  • Release : 1990
  • ISBN : UOM:39015021816627
  • Language : En, Es, Fr & De
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Histopathological assessment of tissue sections is an important componant of many preclinical studies which are conducted to support the safety and clinical development of novel therapeutic agents for use in the treatment of human diseases. The drug discovery process, aided by modern biotechnology, is now capable of generating highly potent, pharmacologically active agents which can give rise to quite unusual constellations of tissue pathology. The complexity and the number of histopathological findings in individual studies indicate the need for lucididy in descriptions and conclusions. In the light of these and other difficulties, this text is aimed towards bringing together into one volume a description of histopathological changes which relate to toxicity testing of therapeutic agents in the usual test species: rat, mouse, dog and non-human primate. This book is an excellent starting point for the analysis of drug-induced findings in toxicity studies.

Histopathology of Preclinical Toxicity Studies


Histopathology of Preclinical Toxicity Studies
  • Author : Peter Greaves
  • Publisher : Elsevier
  • Release : 2007-03-23
  • ISBN : 0080471307
  • Language : En, Es, Fr & De
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This work covers effectively all aspects of drug-induced pathology that may be encountered within preclinical toxicity studies. It fills a gap in the pathology literature relating to the preclinical safety assessment of new medicines. It systematically describes, in one volume, both spontaneous and drug induced pathology on an organ by organ basis. Information relevant to understanding the nature of pathological changes in pre-clinical studies and assessment of their relevance to the clinical investigation of new drugs is also covered. Numerous colour photographs are included that highlight and embellish the histopathological features that are described. It also contains many pertinent references to both human and animal pathology forming an essential basis for the assessment of drug-induced pathology. NEW TO THE THIRD EDITION: * Covers drug induced pathology in preclinical (animal) studies and their relevance for patients or volunteers in clinical studies * General comments to each chapter about the relevance of pathological findings to humans * Provides essential information that can help decide the relevance of particular lesions for patients

A Comprehensive Guide to Toxicology in Preclinical Drug Development


A Comprehensive Guide to Toxicology in Preclinical Drug Development
  • Author : Ali S. Faqi
  • Publisher : Academic Press
  • Release : 2012-11-16
  • ISBN : 9780123878151
  • Language : En, Es, Fr & De
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A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide that outlines day-to-day activities and experiences in preclinical toxicology. This multi-contributed reference provides a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. The book discusses discovery toxicology and the international guidelines for safety evaluation, and presents traditional and nontraditional toxicology models. Chapters cover development of vaccines, oncology drugs, botanic drugs, monoclonal antibodies, and more, as well as study development and personnel, the role of imaging in preclinical evaluation, and supporting materials for IND applications. By incorporating the latest research in this area and featuring practical scenarios, this reference is a complete and actionable guide to all aspects of preclinical drug testing. Chapters written by world-renowned contributors who are experts in their fields Includes the latest research in preclinical drug testing and international guidelines Covers preclinical toxicology in small molecules and biologics in one single source

Background Lesions in Laboratory Animals E Book


Background Lesions in Laboratory Animals E Book
  • Author : Elizabeth Fiona McInnes
  • Publisher : Elsevier Health Sciences
  • Release : 2011-10-24
  • ISBN : 9780702049248
  • Language : En, Es, Fr & De
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Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas. over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals a chapter on common artifacts that may be observed in histological glass slides extensive references to each lesion described aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies