Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases Books

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Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases


Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases
  • Author : Anil Gupta
  • Publisher : Academic Press
  • Release : 2021-12-15
  • ISBN : 0128201223
  • Language : En, Es, Fr & De
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Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases discusses neurodegenerative diseases and their epidemiology and clinical presentation, describes the structural organization of human caspases, their classification, role with mitochondria, and mechanisms of activation, including extensive discussions of neuronal apoptosis and its pathways and underlying mechanisms. Finally, the book discusses the intricate mechanisms and interplay between human caspases and neuronal apoptosis in neurodegenerative diseases. All of this is undercut with extensive coverage of molecular events in the pathogenesis of neurodegenerative disorders. Biomedical researchers, graduate students and scientists, along with neuroscientist and student trainees will greatly benefit from this comprehensive information. Neurodegenerative diseases are characterized by progressive structural and/or functional deterioration and eventual death of affected neurons. The progression of these disorders shares similarities at the molecular level. The programmed cell death manifests as blebbing of the plasma membrane, protein degradation, DNA damage and clearance of dead cells by scavengers. Describes the various intricate mechanisms and interplay between human caspases and neuronal apoptosis in neurodegenerative diseases Provides a detailed description of the structural organization and mechanisms of action of various caspases in regulating the process of apoptosis in neurodegenerative diseases Explores the role of various caspases in cell death

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases


Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases
  • Author : Anil Gupta
  • Publisher : Academic Press
  • Release : 2021-12-01
  • ISBN : 9780128204436
  • Language : En, Es, Fr & De
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Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases discusses neurodegenerative diseases and their epidemiology and clinical presentation, describes the structural organization of human caspases, their classification, role with mitochondria, and mechanisms of activation, including extensive discussions of neuronal apoptosis and its pathways and underlying mechanisms. Finally, the book discusses the intricate mechanisms and interplay between human caspases and neuronal apoptosis in neurodegenerative diseases. All of this is undercut with extensive coverage of molecular events in the pathogenesis of neurodegenerative disorders. Biomedical researchers, graduate students and scientists, along with neuroscientist and student trainees will greatly benefit from this comprehensive information. Neurodegenerative diseases are characterized by progressive structural and/or functional deterioration and eventual death of affected neurons. The progression of these disorders shares similarities at the molecular level. The programmed cell death manifests as blebbing of the plasma membrane, protein degradation, DNA damage and clearance of dead cells by scavengers. Describes the various intricate mechanisms and interplay between human caspases and neuronal apoptosis in neurodegenerative diseases Provides a detailed description of the structural organization and mechanisms of action of various caspases in regulating the process of apoptosis in neurodegenerative diseases Explores the role of various caspases in cell death

Neuronal Cell Death


Neuronal Cell Death
  • Author : Laura Lossi
  • Publisher : Humana Press
  • Release : 2014-11-28
  • ISBN : 1493921517
  • Language : En, Es, Fr & De
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This volume represents a valuable and readily reproducible collection of established and emerging techniques for neuronal cell death research. Conveniently divided into four parts, sections cover a series of techniques for the molecular, structural, functional and genomic characterization of dying neurons, a number of protocols that are of primary interest in neuropathology and in experimental neuropathology, a series of gene engineering techniques to obtain and manipulate neuronal stem cells and progenitors, to prepare HSV-1 vectors for the gene therapy, and to CNS transplantation of bone marrow stem cells, and finally, some very interesting protocols for the study of cell death in non-mammalian models. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Neuronal Cell Death: Methods and Protocols seeks to serve a large audience of scientists that are currently active in the field or are willing to enter such an exciting and still expanding area of neurobiology.

Targeting the Signalling Cascades Responsible for Human Neuronal Apoptosis Elicited by the Lipid Neuromodulator Platelet Activating Factor


Targeting the Signalling Cascades Responsible for Human Neuronal Apoptosis Elicited by the Lipid Neuromodulator Platelet Activating Factor
  • Author : Tia Corinne Moffat
  • Publisher :
  • Release : 2007
  • ISBN : OCLC:871801092
  • Language : En, Es, Fr & De
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Apoptosis is known to underlie neuronal loss in many human neurodegenerative disorders, such as Alzheimer disease (AD), HIV-dementia and ischemic stroke. Phospholipid signalling is involved in each of these conditions; changes in phospholipid membrane composition and phospholipid synthesis enzyme activity occurs in AD, while in HIV-dementia and ischemia there is an increased production and accumulation of inflammatory bioactive phospholipid mediators. Pathophysiological exposure to the phospholipid neuromodulator platelet activating factor (PAF) can initiate apoptotic pathways, and has been hypothesized to be a key mediator of neuronal death in these neurodegenerative disorders. It has been assumed that PAF signals exclusively through its G-protein coupled receptor (PAFR). However, our laboratory has shown that PAF can also induce apoptosis independently of PAFR and that ectopic expression of PAFR renders cells resistant to PAF-induced toxicity. This is relevant to neurodegenerative disease since PAFR expression in the human brain is found predominantly in non-neuronal cells suggesting that PAFR-independent signalling is also involved in neurodegeneration. This thesis focused on elucidating the PAF-induced, PAFR-independent apoptotic pathways in human neurons with the overarching goal of identifying new therapeutic targets capable of inhibiting neuronal loss in neurodegenerative disease. Here, PAF is shown to induce endoplasmic reticulum (ER) stress resulting in caspase-2 activation, leading to the activation of caspase-7, and culminating in DNA fragmentation in human neurons (hNTs) lacking PAFR. Mitochondrial effects, specifically release of cytochrome c from the mitochondria, caspase-9 activation, reactive oxygen species (ROS) production, and mitochondrial uncoupling protein-2 (UCP2) upregulation were initiated downstream of this primary ER cascade. To target this pathway, a panel of natural and synthetic compounds was screened for their ability to protect hNTs from neurotoxicity initiated by PAF and by the AD-related neurotoxic peptide amyloid-beta 1-42 (Abeta). Several compounds were identified as PAF/Abeta inhibitors. One of these compounds, nelfinavir (NFV), was tested for in vivo efficiency using the middle cerebral artery occlusion (MCAO) model of focal ischemia. NFV reduced infarct size, prevented neuronal apoptotic-like death, and improved behavioural recovery, solidifying the relation between PAF, AD, HIV-dementia, and ischemia-induced neuronal apoptosis. Together, these studies demonstrate that PAF can trigger neuronal apoptosis independently of PAFR, that inhibiting PAF-mediated pathways of neurotoxicity can protect human neurons in vitro from PAF and Abeta, and that targeting secondary apoptotic pathways elicited by PAF can reduce neuronal death in vivo in mouse models of human disease. The identification of compounds capable of inhibiting the primary and secondary PAFR-independent apoptotic events triggered by PAF represents a new means of targeting phospholipid signalling in neurodegenerative disease.

Analysis of Triplet Repeat Disorders


Analysis of Triplet Repeat Disorders
  • Author : Michael Hayden
  • Publisher : Garland Science
  • Release : 2020-07-26
  • ISBN : 9781000144703
  • Language : En, Es, Fr & De
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Analysis of Triplet Repeat Disorders is aimed at clinicians and scientists who work with these diseases or who have an interest in the field. Using the clinical picture of these diseases as a starting point, the book reviews and integrates the current understanding of their molecular pathologies, the genotype-phenotype relationships, the mutational processes of trinucleotide repeats, and the laboratory and clinical issues relating to genetic testing for these disorders.