Immunomodulatory Biomaterials Books

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Immunomodulatory Biomaterials


Immunomodulatory Biomaterials
  • Author : Stephen F. Badylak
  • Publisher : Woodhead Publishing
  • Release : 2021-07-15
  • ISBN : 0128214406
  • Language : En, Es, Fr & De
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Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert” immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Biomaterials and Immune Response


Biomaterials and Immune Response
  • Author : Nihal Engin Vrana
  • Publisher : CRC Press
  • Release : 2018-07-20
  • ISBN : 9781351377553
  • Language : En, Es, Fr & De
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The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Immunomodulatory Biomaterials to Mitigate Material induced Host Responses


Immunomodulatory Biomaterials to Mitigate Material induced Host Responses
  • Author : Yoon Kyung Kim
  • Publisher :
  • Release : 2013
  • ISBN : 1303444976
  • Language : En, Es, Fr & De
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The foreign body response to biomaterial implants has been a major challenge in translating many medical devices into the clinic. The presence of inflammatory cells around the implanted device prevents its functional interaction with the surrounding tissue, and although some inflammation may be desirable to mediate the healing process, a persistent inflammatory response will eventually lead to device failure. Significant efforts to reduce foreign body response have been largely focused on developing hydrophilic and anti-fouling coating materials, however, simply preventing protein adsorption and immune cell adhesion has only had moderate success at reducing inflammation in vivo. In this thesis, we describe a novel approach to mitigate the foreign body response, whereby materials are designed to mimic host tissue by displaying endogenously expressed immunomodulatory molecules that interact with specific inhibitory receptors expressed on immune cells. More specifically, biomaterial surfaces are coated with the recombinantly produced immunomodulatory molecule, CD200, which interacts with the inhibitory receptor CD200R on myeloid cells, preventing material-induced host response by suppressing activation of infiltrated myeloid cells. In Chapter One, a brief introduction and background information is presented, followed by a description of the production and purification of recombinant CD200 protein from both mammalian cells and bacterial cells in Chapter Two. In Chapter Three, we examine whether immobilization of CD200 onto polystyrene surfaces influences on suppressing the activation of macrophages. We found that CD200 indeed suppresses the release of inflammatory mediators secreted by macrophage cells in vitro, and elicited less inflammation in vivo when compared to uncoated materials after subcutaneous implantation. In Chapter Four, we examine whether CD200 influences tissue regeneration after spinal cord injury. CD200-embedded fibrin gel was implanted to spinal cord injured mice, and the effect of CD200 on inflammation and regenerative process was examined. Lastly, Chapter Five concludes the work performed in this Ph.D. study and presents future directions. This work suggests that coating of endogenously expressed immunomodulatory proteins can be used as a strategy to reduce inflammatory response to biomaterials and may potentially be generalized to implants throughout the body.

Immunomodulatory Biomaterials


Immunomodulatory Biomaterials
  • Author : Stephen F. Badylak
  • Publisher : Woodhead Publishing
  • Release : 2021-08-05
  • ISBN : 9780128214565
  • Language : En, Es, Fr & De
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Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Biomaterials and Immune Response


Biomaterials and Immune Response
  • Author : Nihal Engin Vrana
  • Publisher : CRC Press
  • Release : 2018-07-20
  • ISBN : 9781351377560
  • Language : En, Es, Fr & De
GET BOOK

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area