Laboratory Exercises in Molecular Pathology Books

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Laboratory Exercises in Molecular Pathology


Laboratory Exercises in Molecular Pathology
  • Author : Jonathon W. Homeister
  • Publisher : Academic Press
  • Release : 2017-10-01
  • ISBN : 0128006080
  • Language : En, Es, Fr & De
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Laboratory Exercises in Molecular Pathology is organized by major organ systems and then by disease type. In each exercise, there is a distillation of essential disease-specific information (related to frequency, risk factors, disease manifestations) and a description of disease pathogenesis (molecular and cellular) that is based upon accepted principles from the literature. Further, each exercise is illustrated with (1) gross specimens, (2) microscopic histopathology, (3) immunohistochemistry and/or in situ hybridization (when applicable), (4) laboratory techniques to probe the molecular nature of the pathological lesions, and (5) molecular diagnostics (when applicable). In addition, each exercise contains one or more cases studies to provide students with exposure to the clinical workup of a patient, based upon physical examination findings, traditional pathological analysis, and state-of-the-art molecular assessment. The laboratory techniques included emphasize the dissection of molecular and cellular pathogenesis of the disease in question. Hence, students will see examples of laboratory results that illustrate how pathways were elucidated. Further, the sections on molecular diagnostics illustrate how molecular testing exploits what is known about molecular pathogenesis in a specific disease setting. The manual does not present molecular methods and techniques in isolation; it illustrates how these experimental approaches and applied methodologies can be used to generate meaningful information in the clinical setting. Presents foundational information, examples of gross and microscopic pathology, and examples of molecular approaches and molecular testing all in one resource Offers an ancillary website with videos corresponding to the evaluation of gross specimens, the assessment of microscopic images, and the demonstration of how laboratory techniques are performed Features exercises which contain one or more cases studies to provide students with exposure to the clinical workup of a patient, based upon physical examination findings, traditional pathological analysis, and state-of-the-art molecular assessment Provides case studies which include self-assessment modules and decision trees that allow students to make mistakes and then receive explanations

Diagnostic Molecular Pathology


Diagnostic Molecular Pathology
  • Author : William B. Coleman
  • Publisher : Academic Press
  • Release : 2016-10-05
  • ISBN : 9780128011577
  • Language : En, Es, Fr & De
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Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). In each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. Sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described. The book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). In addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests. Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. Readers are directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions. Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis, and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for prognostication of disease Features an ancillary website with self-testing exercises where decision trees can be employed to simulate actual clinical decisions Highlights new technologies and approaches of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests

Plant Pathology Concepts and Laboratory Exercises


Plant Pathology Concepts and Laboratory Exercises
  • Author : Bonnie H. Ownley
  • Publisher : CRC Press
  • Release : 2016-11-03
  • ISBN : 9781498774727
  • Language : En, Es, Fr & De
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Continuing in the tradition of its predecessors, this new edition combines an informal, easy to read style with a thorough introduction to concepts and terminology of plant pathology. After reviewing fundamental concepts, the book discusses groups of plant pathogens and molecular tools for studying them, pathogen interactions, epidemiology and disease control, and special topics in plant pathology. The book details various disease-causing organisms, including viruses, fungi, prokaryotics, nematodes, and various biotic agents. It also examines various plant-pathogen interactions, molecular attack strategies, extracellular enzymes, host defenses, and disruption of plant function. New in the Third Edition Molecular plant-fungal interactions Expanded treatment of molecular tools Advanced biocontrol concepts How to use and care for microscopes

Molecular Diagnostics


Molecular Diagnostics
  • Author : George P. Patrinos
  • Publisher : Academic Press
  • Release : 2016-10-27
  • ISBN : 9780128029886
  • Language : En, Es, Fr & De
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Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management. Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field

Plant Pathology Concepts and Laboratory Exercises Second Edition


Plant Pathology Concepts and Laboratory Exercises  Second Edition
  • Author : Robert N. Trigiano
  • Publisher : CRC Press
  • Release : 2008
  • ISBN : STANFORD:36105124027736
  • Language : En, Es, Fr & De
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Including contributions from specialists with extensive experience in the field, this second edition features new chapters on pathogenic prokaryotes, soilborne pathogens, and host-pathogen interactions. It increases coverage of a number of molecular techniques-including real-time PCR methods for pathogen detection, AFLPs, and AGDIA methods-and insect vectoring of bacterial pathogens with potential control strategies. A more detailed discussion of disease diagnosis is also provided. An accompanying CD-ROM offers a wide range of full-colour illustrations to enhance understanding of concepts. Additional references and case studies have been added to the text.