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Mechanisms of Cell Death and Opportunities for Therapeutic Development


Mechanisms of Cell Death and Opportunities for Therapeutic Development
  • Author : Diaqing Liao
  • Publisher : Academic Press
  • Release : 2021-11-15
  • ISBN : 0128142081
  • Language : En, Es, Fr & De
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Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years' experience teaching topics of cell death. Provides a comprehensive overview of current knowledge on the process of apoptosis, its potential role in health and disease, and a discussion of potential alternative forms, such as autophagy Covers fundamental mechanisms and relevant translational research

Sixth Euroconference on Mechanisms of Cell Death and Disease


Sixth     Euroconference on Mechanisms of Cell Death and Disease
  • Author :
  • Publisher :
  • Release : 2006
  • ISBN : OCLC:708295103
  • Language : En, Es, Fr & De
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Cell Death


Cell Death
  • Author : Hao Wu
  • Publisher : Springer Science & Business Media
  • Release : 2013-11-19
  • ISBN : 9781461493020
  • Language : En, Es, Fr & De
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Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy. Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response. When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death. At the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively. The molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway. Key players in these pathways, such as the Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death receptor adapter proteins, and inhibitor of apoptosis proteins, are presented from both functional and structural angles. Until only a few years ago, programmed cell death has been considered essentially synonymous with apoptosis. However, we now know that programmed cell death can also take other forms such as necrosis or necroptosis, and to this end, the mechanisms that underlie programmed necrosis in development and host defense are illustrated. The past twenty plus years have seen an incredible growth of research in cell death, with one breakthrough after another, and the legacy still goes on with constant new surprises and findings. Long live cell death!

Death Receptors in Cancer Therapy


Death Receptors in Cancer Therapy
  • Author : Wafik S. El-Deiry
  • Publisher : Springer Science & Business Media
  • Release : 2007-11-15
  • ISBN : 9781592598519
  • Language : En, Es, Fr & De
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An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Mechanisms of Cell Death


Mechanisms of Cell Death
  • Author : Cell Death Society
  • Publisher :
  • Release : 1999
  • ISBN : 1573312401
  • Language : En, Es, Fr & De
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As the body of research on apoptosis grows, it paradoxically becomes simpler as the principles that define the field become more flexible and inclusive. Discussions of the role of cell death in AIDS, inflammatory disease, lung and cardiac disease, and lupus each emphasize the importance of understanding and regulating inflammation and the production of apoptotic bodies. Included in these proceedings is an in-depth review of the role of death cell genes, including intriguing studies of the existence of inhibitors of apoptosis in embryos. Many of these researchers now feel it is a combination, rather than any single gene, that activates apoptosis.