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Acta Histochemica


Acta Histochemica
  • Author :
  • Publisher :
  • Release : 1958
  • ISBN : UCLA:31158010902269
  • Language : En, Es, Fr & De
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Issues for 1958-1992 include proceedings of the Arbeitsgemeinschaft für Histochemie.

Targeting of Drugs


Targeting of Drugs
  • Author : Gregory Gregoriadis
  • Publisher : IOS Press
  • Release : 2000
  • ISBN : 1586030094
  • Language : En, Es, Fr & De
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Gene therapy, developed as an alternative to the use of therapeutic proteins, can be hampered by nuclease degradation of the plasmid DNA, its inability to access target cells, or - when within cells - to enter the nucleus and transfect these efficiently. This text deals with developments in circumventing the problems of direct plasmid administration by the use of viral or non-viral vectors, Representatives from both camps of therapy discuss the challenges and opportunities of the two approaches and present late-20th-century progress with a variety of constructs. These include viruses such as retroviruses, lentiviruses, poxviruses, alphavirus, herpevirus, and parvovirus. Non-viral constructs are represented by polycations, polymers, cationic liposomes and nanoparticles.

Molecular Basis of Neurological Disorders and Their Treatment


Molecular Basis of Neurological Disorders and Their Treatment
  • Author : J.W. Gorrod
  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • ISBN : 9789401131148
  • Language : En, Es, Fr & De
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cytochemical techniques (ICC) which provide a useful adjunct to investigations by immunoblotting. A particular advantage of a cytochemical approach to the investiga tion of mitochondrial disorders is that it allows the mosaic distribution of certain of these defects to be detected, whereas the tissue homogeniza tion involved in conventional enzyme assays or immunoblotting precludes this. A further advantage of MEA or ICC is that only small amounts of tissue are needed, which is important since many of the affected patients are infants or small children. The main aim of this communica tion is to outline ways in which these techniques can be used in the diagnosis and further investigation of mitochondrial disorders. Reference will be made not only to those situations in which MEA and ICC offer advantages over standard enzyme asays and immunoblotting but also to contexts in which the reverse applies. 4. 2 MATERIALS AND METHODS Muscle biopsies for cytochemical investigation were snap-frozen using isopentane cooled to - 150°C in liquid nitrogen. Samples were stored in heat-sealed polythene packets in the vapour phase of liquid nitrogen containers. 4. 2. 1 Microphotometric enzyme assays Frozen sections 8 Jlm thick were cut using a Reichert-J ung Frigocut cryostat microtome equipped with motor-driven cutting action to maintain maximal reproducibility of section thickness. Sections were picked up on microscope slides and air-dried for 15 min at room temperature.

National Library of Medicine Current Catalog


National Library of Medicine Current Catalog
  • Author : National Library of Medicine (U.S.)
  • Publisher :
  • Release : 1989
  • ISBN : MINN:31951D00419853V
  • Language : En, Es, Fr & De
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Current Catalog


Current Catalog
  • Author :
  • Publisher :
  • Release : 1989
  • ISBN : UOM:39015074107601
  • Language : En, Es, Fr & De
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First multi-year cumulation covers six years: 1965-70.