Molecular Biology of B Cells Books

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Molecular Biology of B Cells


Molecular Biology of B Cells
  • Author : Tasuku Honjo
  • Publisher : Elsevier
  • Release : 2014-10-09
  • ISBN : 9780123984906
  • Language : En, Es, Fr & De
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Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. Covers signaling mechanisms regulating B cell differentiation Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab Contains studies on B cell tumors from various stages of B lymphocytes Offers an integrated view of all aspects of B cells to produce a normal immune response

Molecular Biology of B Cell and T Cell Development


Molecular Biology of B Cell and T Cell Development
  • Author : John G. Monroe
  • Publisher : Springer Science & Business Media
  • Release : 2013-03-14
  • ISBN : 9781475727784
  • Language : En, Es, Fr & De
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Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.

B Cell Biology in Autoimmunity


B Cell Biology in Autoimmunity
  • Author : David Ahmad Nemazee
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 2003
  • ISBN : 9783805574549
  • Language : En, Es, Fr & De
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B cells play a central role not only in adaptive immunity, but also in autoimmunity. To understand how B cells are normally prevented from reacting to self-tissue, what goes wrong in autoimmunity, and how B cells contribute to it is the aim of this book. This volume includes more than a dozen in-depth reviews by researchers specializing in various aspects of basic B cell biology that have relevance to autoimmune diseases. These up-to-date chapters present the latest information on B cell signal transduction, apoptosis, genetics and molecular biology. Also featured are chapters with special reference to particular autoimmune diseases in which B cells have been shown to play a critical role, such as type 1 diabetes, chronic graft-versus-host disease and lupus erythematosus. Further topics covered include the role of the complement system, rheumatoid factors, and anti-DNA autoantibodies as well as important related areas such as natural autoantibodies, B cell immune tolerance, Toll receptor signaling, and the immunobiology of BAFF/BLyS. Both basic researchers and clinician scientists who wish to understand the role of B lymphocytes in immune tolerance and autoimmunity will benefit from this timely publication.

B Cell Protocols


B Cell Protocols
  • Author : Hua Gu (PhD.)
  • Publisher : Springer Science & Business Media
  • Release : 2004
  • ISBN : 9781592597963
  • Language : En, Es, Fr & De
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A diverse collection of protocols ranging from the latest inventions and applications to some classic, but still frequently used, methods for studying B-lymphocyte development and function in higher animals. These readily reproducible protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Readily reproducible techniques for studying B-lymphocyte development and function Comprehensive collection of classic and cutting-edge methods Step-by-step instructions that ensure experimental success.

Molecular Biology of the Cell


Molecular Biology of the Cell
  • Author : Bruce Alberts
  • Publisher :
  • Release : 2004
  • ISBN : 0815332181
  • Language : En, Es, Fr & De
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