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Natural Hosts of SIV


Natural Hosts of SIV
  • Author : Aftab A. Ansari
  • Publisher : Newnes
  • Release : 2014-07-04
  • ISBN : 9780124051676
  • Language : En, Es, Fr & De
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Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant. Summarizes the past 30 years of research in this field and describes the latest developments in AIDS research using nonhuman primate animal models Provides insights into how this large body of scientific work can be translated into novel approaches to treat and prevent HIV Highlights the areas that merit future pursuit, focusing on potential applications for the treatment and prevention of HIV infection

The Evolution of HIV


The Evolution of HIV
  • Author : Keith A. Crandall
  • Publisher : JHU Press
  • Release : 1999-04-26
  • ISBN : 0801861519
  • Language : En, Es, Fr & De
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"As a model for viral evolution, this book is a gold mine." -- European Molecular Biology Organization Reports

Models of Protection Against HIV SIV


Models of Protection Against HIV SIV
  • Author : Gianfranco Pancino
  • Publisher : Academic Press
  • Release : 2012-01
  • ISBN : 9780123877154
  • Language : En, Es, Fr & De
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A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field

Encyclopedia of AIDS


Encyclopedia of AIDS
  • Author : Thomas J. Hope
  • Publisher : Springer
  • Release : 2018-02-22
  • ISBN : 149397100X
  • Language : En, Es, Fr & De
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For the first time, the world’s experts in HIV-AIDS have come together to publish the Encyclopedia of AIDS. The work features over 4000 A-Z entries including medical, cultural, social, and pharmacological essays. The Pathology entries cover the various types of HIV-related illnesses, including those that are and are not AIDS-defining. Many of the conditions that are AIDS-defining illnesses have their own entries or are cross-referenced to a generic entry in which several related conditions are discussed (such as enteric diseases and fungal infections). Typically, the treatment of any given form of pathology is briefly discussed in the entry that covers that illness. The reference is a must-read for Infectious Disease specialists, Immunologists, Public Health researchers, Virologists, Microbiologists, Pharmacologists, and Physicians.

AIDS Pathogenesis


AIDS Pathogenesis
  • Author : H. Schuitemaker
  • Publisher : Springer Science & Business Media
  • Release : 2000-03-31
  • ISBN : 0792361962
  • Language : En, Es, Fr & De
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Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.