Non-Enzymatic Protein Modifications in Health, Disease and Ageing Books

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Non Enzymatic Protein Modifications in Health Disease and Ageing


Non Enzymatic Protein Modifications in Health  Disease and Ageing
  • Author : Izabela Sadowska-Bartosz
  • Publisher : Academic Press
  • Release : 2018-11-15
  • ISBN : 0128143053
  • Language : En, Es, Fr & De
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There is increased understanding of the fate of intracellular and extracellular proteins, including the many types of posttranslational modifications that proteins undergo. Among these modifications, non-enzymatic protein modifications play a special role. These are unavoidable products of side reactions of reactive metabolites, and often damage proteins and induce loss of function. Non-Enzymatic Protein Modifications in Health, Diseases and Ageing discusses each type of non-enzymatic protein, both introducing non-enzymatic protein modifications, and reviewing the state of the art, presenting updates and current trends. The book covers various aspects of the subject, including formation and removal of modified proteins, their roles in disease, preventative methods, and possible roles in cellular signalling. Finally, the book not only provides well-established facts, but also discusses current hypotheses and controversies. Provides the basic chemical knowledge necessary to understand non-enzymatic protein modifications, of particular use to researchers looking for an introduction to and overview of the field Combines a systematic chemical introduction to non-enzymatic protein modifications with a review of the state of the art Presents together, types of non-enzymatic protein usually reported and reviewed separately Considers current hypotheses and controversies alongside the facts

Vital Dust


Vital Dust
  • Author : Christian De Duve
  • Publisher : Basic Books
  • Release : 1995-01-03
  • ISBN : UCSD:31822028296507
  • Language : En, Es, Fr & De
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Is the emergence of life on Earth the result of a single chance event or combination of lucky accidents, or is it the outcome of biochemical forces woven into the fabric of the universe? And if inevitable, what are these forces, and how do they account not only for the origin of life but also for its evolution toward increasing complexity? Vital Dust is a groundbreaking history of life on Earth, a history that only someone of Chrisitian de Duve's stature and erudition could have written.

Molecular Basis and Emerging Strategies for Anti aging Interventions


Molecular Basis and Emerging Strategies for Anti aging Interventions
  • Author : Syed Ibrahim Rizvi
  • Publisher : Springer
  • Release : 2018-11-02
  • ISBN : 9789811316999
  • Language : En, Es, Fr & De
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This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions – including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction – that will be of interest to scientists and researchers from various disciplines in the life sciences.

Protein Metabolism and Homeostasis in Aging


Protein Metabolism and Homeostasis in Aging
  • Author : Nektarios Tavernarakis
  • Publisher : Springer Science & Business Media
  • Release : 2011-01-11
  • ISBN : 9781441970022
  • Language : En, Es, Fr & De
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Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data. Protein turnover, the balance between protein synthesis and protein degradation are carefully maintained in healthy cells. Chapters 1 and 2 illustrate that aging cells are characterised by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation, essential for cell growth and survival, is controlled at multiple levels. The theory that growth and somatic maintenance are believed to be antagonistic processes is described in Chapter 3: inhibition of protein synthesis results in decreased rates of growth and development, but also confers an extension of lifespan, as shown for example by the effects of dietary restriction in various models organisms.

Providing Healthy and Safe Foods As We Age


Providing Healthy and Safe Foods As We Age
  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release : 2010-11-29
  • ISBN : 9780309158831
  • Language : En, Es, Fr & De
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Does a longer life mean a healthier life? The number of adults over 65 in the United States is growing, but many may not be aware that they are at greater risk from foodborne diseases and their nutritional needs change as they age. The IOM's Food Forum held a workshop October 29-30, 2009, to discuss food safety and nutrition concerns for older adults.