Nonclinical Assessment of Abuse Potential for New Pharmaceuticals Books

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Nonclinical Assessment of Abuse Potential for New Pharmaceuticals


Nonclinical Assessment of Abuse Potential for New Pharmaceuticals
  • Author : Carrie Markgraf
  • Publisher : Academic Press
  • Release : 2015-07-14
  • ISBN : 9780124202160
  • Language : En, Es, Fr & De
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Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability. Provides a consolidated overview of the complex regulatory landscape Offers best practice methodology for conducting animal studies, including selection of doses and positive control agents that will help you improve your own abuse potential studies Includes real-life examples to illustrate how nonclinical data fit into the submission strategy

Stem Cells in Toxicology and Medicine


Stem Cells in Toxicology and Medicine
  • Author : Saura C. Sahu
  • Publisher : John Wiley & Sons
  • Release : 2016-10-13
  • ISBN : 9781119135425
  • Language : En, Es, Fr & De
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A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine Presented by internationally recognized investigators in this exciting field of scientific research Provides an insight into the current trends and future directions of research in this rapidly developing new field A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment


The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment
  • Author : Joerg Bluemel
  • Publisher : Academic Press
  • Release : 2015-03-13
  • ISBN : 9780124171466
  • Language : En, Es, Fr & De
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The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Assessment of Substance Abuse


Assessment of Substance Abuse
  • Author : Linda L. Murphy
  • Publisher : Buros Desk Reference
  • Release : 1996
  • ISBN : 0910674426
  • Language : En, Es, Fr & De
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The Buros Desk Reference series contains reviews of test instruments commonly used in particular areas. Assessment of Substance Abuse is an indispensable resource for counselors, psychologists, researchers, and others who work with substance abuse issues. Reviews and descriptive information are provided for almost seventy commercially available instruments used in the identification and treatment of substance abuse and related problems. These reviews are taken from the ninth, tenth, eleventh, twelfth, and thirteenth editions of the Mental Measurements Yearbook and represent virtually all commercially available tests in this area. This volume includes titles, acronym, and score indexes and a publishers directory. The convenient size and easy-to-locate information in this book make it an ideal desktop companion.

Principles of Safety Pharmacology


Principles of Safety Pharmacology
  • Author : Michael K. Pugsley
  • Publisher : Springer
  • Release : 2015-06-19
  • ISBN : 9783662469439
  • Language : En, Es, Fr & De
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This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.