Spinal Cord Injury (SCI) Repair Strategies Books

Click Get Book Button To Download or read online Spinal Cord Injury (SCI) Repair Strategies books, Available in PDF, ePub, Tuebl and Kindle. This site is like a library, Use search box in the widget to get ebook that you want.

Spinal Cord Injury SCI Repair Strategies


Spinal Cord Injury  SCI  Repair Strategies
  • Author : Giuseppe Perale
  • Publisher : Woodhead Publishing
  • Release : 2019-10-30
  • ISBN : 9780081028087
  • Language : En, Es, Fr & De
GET BOOK

Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering

Promoting Neuroplasticity to Repair the Injured Spinal Cord


Promoting Neuroplasticity to Repair the Injured Spinal Cord
  • Author : Nina Weishaupt
  • Publisher :
  • Release : 2013
  • ISBN : OCLC:871700569
  • Language : En, Es, Fr & De
GET BOOK

This thesis explores strategies to promote neuronal plasticity in a rat model of cervical spinal cord injury (SCI) in an effort to achieve improved recovery of skilled forelimb use. I focused on investigating how motor pathways disrupted by an SCI may connect to spared, lesion-bridging relay pathways to re-establish communication with target regions below the injury level. In chapter 2, I attempted to promote a detour for the cervically injured corticospinal tract (CST) via spared reticulospinal tract (RtST) axons with a combined treatment including the neurotrophins BDNF, NT-3 and rehabilitative training. Although anatomical evidence for the desired rewiring was not obtained, I found a synergistic effect of BDNF treatment and training on recovery of skilled forelimb reaching. No effect of NT-3 administered rostral to the SCI was evident. The experiment in chapter 3 was designed to answer the question whether NT-3-induced CST collateral growth rostral to an SCI can be facilitated by systemic immune activation. Results indicate that NT-3 expression can promote collateral growth from the injured CST, irrespective of immune activation. Since results from chapter 2 did not shed light on the previously suggested role of the RtST in recovery of hand/paw function after cervical SCI, I next examined whether the mostly spared RtST responds to SCI with changes in its anatomical projection pattern. While collateral projections were unchanged rostral to the SCI, I observed a marked withdrawal of collaterals from grey matter regions directly caudal to the SCI. Results from chapter 2 combined with previous reports indicate that task-specific training does often not translate into untrained tasks and may even result in undesired side effects. To elucidate the functional relationship between trained tasks further, I next investigated how training the primarily affected forelimb (PAF) and/or the less affected forelimb (LAF) after unilateral cervical SCI influences performance outcomes for each limb. Results point towards training tasks competitively recruiting available neuronal "hardware". This work identifies promising leads for promoting plasticity of important motor tracts after SCI, and also points out targets for optimization of strategies employed. These new insights contribute to the exploration of urgently needed repair strategies for SCI.

Neurobiology of Spinal Cord Injury


Neurobiology of Spinal Cord Injury
  • Author : Robert G. Kalb
  • Publisher : Springer Science & Business Media
  • Release : 1999-10-22
  • ISBN : 9781592592005
  • Language : En, Es, Fr & De
GET BOOK

Distinguished researchers review the latest scientific understanding of spinal cord injury (SCI), focusing on the mechanisms causing paralysis after spinal cord trauma, the molecular determinants of neural regeneration, and methods for improving damaged function. The authors examine the role of intracellular Ca2+ in neuronal death, the possibility of spinal learning, growth-promoting molecules for regenerating neurons, and the biochemistry and cell biology of microtubules. Among the treatment possibilities discussed are cell transplantation strategies beyond the use of fetal spinal cord tissue, remyelination in spinal cord demyelination models, high steroid therapy immediately after SCI, and the mixed use of anti- and proinflammatories. Comprehensive and highly promising, Neurobiology of Spinal Cord Injury summarizes and integrates the great progress that has been made in understanding and combating the paralysis that follows spinal cord injury.

Biomimetic Materials And Design


Biomimetic Materials And Design
  • Author : Angela Dillow
  • Publisher : CRC Press
  • Release : 2002-08-28
  • ISBN : 020390897X
  • Language : En, Es, Fr & De
GET BOOK

Detailing techniques in wound healing and reconstruction, this reference describes the mechanisms and architecture of biological systems to formulate and design natural and synthetic compounds, degradable and non-degradable scaffolds, and targeted drug delivery devices. It offers strategies to control adhesive interactions, elicit specific cellular responses, and improve the biocompatibility, performance, and durability of prosthetic materials. Covering advances in the field, the book discusses the effect of topographical features on cell behaviors such as orientation, adhesion, migration, proliferation, and differentation.

Spinal Cord Injury Rehabilitation


Spinal Cord Injury Rehabilitation
  • Author : Edelle Field-Fote
  • Publisher : F.A. Davis
  • Release : 2009-03-26
  • ISBN : 9780803623194
  • Language : En, Es, Fr & De
GET BOOK

One of the world’s leading authorities in spinal cord injury, and a participant in the Human Brain Project brings you an evidenced-based guide to the state-of-the-art in spinal cord rehabilitation. She has assembled an expert team of clinicians, each with expertise in the content areas they address. Their work encompasses all of the new scientific knowledge and technological advances practitioners need to know to determine the most effective rehabilitation interventions for each patient and to attain maximum restoration of function in individuals with SCI.