The Practice of Medicinal Chemistry Books

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The Practice of Medicinal Chemistry


The Practice of Medicinal Chemistry
  • Author : Camille Georges Wermuth
  • Publisher : Elsevier
  • Release : 2015-07-01
  • ISBN : 9780124172135
  • Language : En, Es, Fr & De
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The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

The Handbook of Medicinal Chemistry


The Handbook of Medicinal Chemistry
  • Author : Andrew Davis
  • Publisher : Royal Society of Chemistry
  • Release : 2015-07-07
  • ISBN : 9781782621836
  • Language : En, Es, Fr & De
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Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book helps readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to enable medicinal chemists to apply their academic understanding to every aspect of drug discovery. Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development.

The Practice of Medicinal Chemistry


The Practice of Medicinal Chemistry
  • Author : C. G. Wermuth
  • Publisher :
  • Release : 1996
  • ISBN : UOM:39015038937986
  • Language : En, Es, Fr & De
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This book collects in one single volume, the practical aspects of Medicinal Chemistry, seen from a chemical point of view, including the wealth of information which chemists accumulate over a career, but generally is never organized and presented in a coherent form in print. Emphasis is given to how medicinal chemists conduct their search for, and design of, new drug entities. In contrast to other books on the market, it focuses on the chemistry, rather than pharmacological concepts or description of the various therapeutic classes of drugs. It should become a standard reference on the tools available to medicinal chemists when designing new drugs. Key Features * These aspects are covered by: * Specific chapters devoted to the discovery of new lead compounds, including combinatorial chemistry * Clearly written chapters on modern topics such as stereochemical aspects of drug action, the use of X-ray structures of receptors and enzymes in drug discovery, and the contribution of molecular biology to drug discovery * Guidelines and operational strategems allowing identification of the portions of the molecule which are important for potency * The particular emphasis given to the three-dimensional aspects of the drug-receptor interactions, to the design of peptidomimetic drugs and to the control of the agonist-antagonist transition * Chemical solutions to solubility and to formulation problems These sections cover perhaps the most neglected areas in medicinal chemistry books * Development of new drugs: legal and economic aspects, constitutes another important area in which chemists are almost wholly self taught following their entry into industry

Basic Concepts in Medicinal Chemistry


Basic Concepts in Medicinal Chemistry
  • Author : Marc Harrold
  • Publisher : ASHP
  • Release : 2013-01-18
  • ISBN : 9781585283644
  • Language : En, Es, Fr & De
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Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. Key features include: • Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups. • How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism. • Numerous examples and expanded discussions for complex concepts. • Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice. • An overview of structure activity relationships (SARs) and concepts that govern drug design. • Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix. Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry. About the Authors Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy. Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.

Medicinal Chemistry


Medicinal Chemistry
  • Author : Frank D. King
  • Publisher :
  • Release : 2002
  • ISBN : UOM:39015056451621
  • Language : En, Es, Fr & De
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This is an valuable introduction to medicinal chemistry for new graduates and PhDs. It will also serve to update more experienced scientists on the newer technologies in the field.