YY1 is Pivotal in the Control of the Pathogenesis and Drug Resistance of Cancer Books

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YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer


YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer
  • Author : Benjamin Bonavida
  • Publisher : Academic Press
  • Release : 2020-11-02
  • ISBN : 9780128226360
  • Language : En, Es, Fr & De
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YY1 Is Pivotal in the Control of the Pathogenesis and Drug Resistance of Cancer: A Critical Therapeutic Target describes the current state-of-the-art of the transcription factor YY1 that is overexpressed in the majority of cancers and a central factor that regulates all of the major features and characteristics of human cancers. This book emphasizes the biochemical, molecular and genetic underlying mechanisms by which YY1 regulates its pro-cancerous activities. In addition, it also describes the role of YY1 in the regulation of tumor cell resistance to conventional chemo and immunotherapies and the important role of inhibiting YY1 in cancer. This book is a valuable source for cancer researchers, oncologists and several members of medical and biomedical field who are interested in understanding further the role of YY1 in cancer. Provides a thorough understanding of the underlying mechanisms by which YY1 regulates cancer cell phenotype and unique characteristics Discusses the novel mechanisms of YY1 regulation of tumor cell resistance and means to overcome resistance Encompasses new examples of newly developed non-toxic and selective inhibitors targeting YY1

Sensitization of Cancer Cells for Chemo Immuno Radio therapy


Sensitization of Cancer Cells for Chemo Immuno Radio therapy
  • Author : Benjamin Bonavida
  • Publisher : Springer Science & Business Media
  • Release : 2008-07-31
  • ISBN : 1597454745
  • Language : En, Es, Fr & De
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This book reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. It also introduces several current approaches developed by established investigators that are aimed at overcoming resistance. This is the first volume to compile studies on tumor cell sensitization. It will prove useful for students, scientists, clinicians and pharmaceutical companies.

Prognostic and Therapeutic Applications of Rkip in Cancer


Prognostic and Therapeutic Applications of Rkip in Cancer
  • Author : Benjamin Bonavida
  • Publisher : Academic Press
  • Release : 2020-03-02
  • ISBN : 9780128196120
  • Language : En, Es, Fr & De
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Prognostic and Therapeutic Applications of RKIP in Cancer provides updated reviews on the chemistry, signaling, pre-clinical and clinical activities, and role of RKIP expression levels for diagnostics, prognosis and potential interventions. The development of novel compounds and conjugates that selectively induce RKIP expression in cancer open a novel era of new therapeutics and their potential in the treatment of highly resistant cancers and metastases. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides an update from experts in the field on diagnostics, prognostics and therapeutics Brings a clear overview of recent findings and references, as well as summaries, significant molecular pathways, and conclusions in each chapter Provides a general introductory chapter on contributions in the field and a chapter summary, with synthesized findings and a projection of future goals

Tumor Microenvironment and Cellular Stress


Tumor Microenvironment and Cellular Stress
  • Author : Constantinos Koumenis
  • Publisher : Springer Science & Business Media
  • Release : 2013-11-23
  • ISBN : 9781461459156
  • Language : En, Es, Fr & De
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The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.

Current Applications for Overcoming Resistance to Targeted Therapies


Current Applications for Overcoming Resistance to Targeted Therapies
  • Author : Myron R. Szewczuk
  • Publisher : Springer
  • Release : 2019-07-15
  • ISBN : 9783030214777
  • Language : En, Es, Fr & De
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Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome resistance to targeted therapy. This book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. Subject experts provide a comprehensive overview of the challenges and solutions to resistance to several conventional targeted therapies in addition to providing a discussion on broad topics including targeting components of the tumor microenvironment, emerging therapeutic options, and novel areas to be explored concerning nanotechnology and the epigenome.